Zika Virus in Peridomestic Neotropical Primates, Northeast Brazil
- 28 January 2019
- journal article
- research article
- Published by Springer Science and Business Media LLC in Ecohealth
- Vol. 16 (1), 61-69
- https://doi.org/10.1007/s10393-019-01394-7
Abstract
Zika virus (ZIKV) is a mosquito-borne viral disease associated with fetal microcephaly and other central nervous system (CNS) symptomatology. It was first identified in a Rhesus macaque in Uganda in 1947 and later in humans (Zika fever). In 2015, ZIKV was notified in Northeast Brazil where it was associated with CNS alterations and with rapid epidemic spread. Considering that ZIKV infects Old World monkeys, the aim of this study was to follow its potential in neotropical primates. Here, we show the detection of ZIKV in marmosets and capuchin monkeys captured in Ceara state, Northeast Brazil. Nine (9/132) samples were positive by quantitative RT-PCR assay. Neutralizing antibodies in primates for ZIKV were also detected by PRNT. The ZIKV-positive samples were obtained from peridomestic animals captured in proximity to humans in areas with reports of ZIKV-associated microcephaly cases during the epidemic period. These results reiterate the molecular evidence of ZIKV infection in neotropical primates, and the temporal detection suggests that detection in primates occurred during the epidemic period in humans. However, a continuous surveillance is necessary to exclude the possibility of virus circulation and transmission in wild environments.Keywords
Funding Information
- Coordination for the Improvement of Higher Level, or Education, Personnel - CAPES (88887.13138712016/2016-00)
- National Council for Scientific and Technological Development ? CNPq
- A Fundação de Amparo à Pesquisa do Estado de São Paulo (2014/16333-1)
This publication has 29 references indexed in Scilit:
- Callithrix penicillata: A feasible experimental model for dengue virus infectionImmunology Letters, 2014
- Demonstration of marmosets (Callithrix jacchus) as a non-human primate model for secondary dengue virus infection: high levels of viraemia and serotype cross-reactive antibody responses consistent with secondary infection of humansJournal of General Virology, 2014
- Zika Virus in Gabon (Central Africa) – 2007: A New Threat from Aedes albopictus?PLoS Neglected Tropical Diseases, 2014
- Fever versus fever: The role of host and vector susceptibility and interspecific competition in shaping the current and future distributions of the sylvatic cycles of dengue virus and yellow fever virusInfection, Genetics and Evolution, 2013
- Common marmoset (Callithrix jacchus) as a primate model of dengue virus infection: development of high levels of viraemia and demonstration of protective immunityJournal of General Virology, 2011
- Zika Virus Outside AfricaEmerging Infectious Diseases, 2009
- Genetic and Serologic Properties of Zika Virus Associated with an Epidemic, Yap State, Micronesia, 2007Emerging Infectious Diseases, 2008
- A simple technique for infection of mosquitoes with viruses transmission of zika virusTransactions of the Royal Society of Tropical Medicine and Hygiene, 1956
- Zika virus (II). Pathogenicity and physical propertiesTransactions of the Royal Society of Tropical Medicine and Hygiene, 1952
- Zika Virus (I). Isolations and serological specificityTransactions of the Royal Society of Tropical Medicine and Hygiene, 1952