Statins and neuroprotection
- 17 June 2010
- journal article
- review article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 1199 (1), 69-76
- https://doi.org/10.1111/j.1749-6632.2009.05359.x
Abstract
There is growing interest in the use of statins, HMG‐CoA reductase inhibitors, for treating specific neurodegenerative diseases (e.g., cerebrovascular disease, Parkinson's disease, Alzheimer's disease, multiple sclerosis) and possibly traumatic brain injury. Neither is there a consensus on the efficacy of statins in treating the aforementioned diseases nor are the mechanisms of the purported statin‐induced neuroprotection well‐understood. Part of the support for statin‐induced neuroprotection comes from studies using animal models and cell culture. Important information has resulted from that work but there continues to be a lack of progress on basic issues pertaining to statins and brain that impedes advancement in understanding how statins alter brain function. For example, there are scant data on the pharmacokinetics of lipophilic and hydrophilic statins in brain, statin‐induced neuroprotection versus cell death, and statins and brain isoprenoids. The purpose of this mini‐review will be to examine those aforementioned issues and to identify directions of future research.Keywords
This publication has 57 references indexed in Scilit:
- Simvastatin induces cell death in a mouse cerebellar slice culture (CSC) model of developmental myelinationExperimental Neurology, 2009
- Rosuvastatin induces delayed preconditioning against oxygen-glucose deprivation in cultured cortical neuronsAmerican Journal of Physiology-Cell Physiology, 2009
- Isoprenoid quantitation in human brain tissue: a validated HPLC–fluorescence detection method for endogenous farnesyl- (FPP) and geranylgeranylpyrophosphate (GGPP)Analytical and Bioanalytical Chemistry, 2008
- Statin use and the risk of Parkinson diseaseNeurology, 2008
- Statin Therapy for Stroke PreventionStroke, 2008
- Simvastatin protects neurons from cytotoxicity by up‐regulating Bcl‐2 mRNA and proteinJournal of Neurochemistry, 2007
- Isoprenoids and Alzheimer's disease: A complex relationshipNeurobiology of Disease, 2006
- PLEIOTROPIC EFFECTS OF STATINSAnnual Review of Pharmacology and Toxicology, 2005
- Statins Cause Intracellular Accumulation of Amyloid Precursor Protein, β-Secretase-cleaved Fragments, and Amyloid β-Peptide via an Isoprenoid-dependent MechanismOnline Journal of Public Health Informatics, 2005
- Statins: drugs for Alzheimer’s disease?Journal of Neural Transmission, 2005