Metagenomic approaches to natural products from free-living and symbiotic organisms
- 16 September 2009
- journal article
- review article
- Published by Royal Society of Chemistry (RSC) in Natural Product Reports
- Vol. 26 (11), 1488-1503
- https://doi.org/10.1039/b817078a
Abstract
Covering: up to the end of January 2009Bacterial cultivation has been a mainstay of natural products discovery for the past 80 years. However, the majority of bacteria are recalcitrant to culture, providing an untapped source for new natural products. Metagenomic analysis provides an alternative method to directly access the uncultivated genome for natural products research and for the discovery of novel, bioactive substances. Applications of metagenomics to diverse habitats, such as soils and the interior of animals, are described.Keywords
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