Controversies surrounding human papilloma virus infection, head & neck vs oral cancer, implications for prophylaxis and treatment
Open Access
- 30 March 2009
- journal article
- Published by Springer Science and Business Media LLC in Head & Neck Oncology
- Vol. 1 (1), 8
- https://doi.org/10.1186/1758-3284-1-8
Abstract
Head & Neck Cancer (HNC) represents the sixth most common malignancy worldwide and it is historically linked to well-known behavioural risk factors, i.e., tobacco smoking and/or the alcohol consumption. Recently, substantial evidence has been mounting that Human Papillomavirus (HPV) infection is playing an increasing important role in oral cancer. Because of the attention and clamor surrounding oral HPV infection and related cancers, as well as the use of HPV prophylactic vaccines, in this invited perspective the authors raise some questions and review some controversial issues on HPV infection and its role in HNC, with a particular focus on oral squamous cell carcinoma.Keywords
This publication has 78 references indexed in Scilit:
- Dysregulated molecular networks in head and neck carcinogenesisOral Oncology, 2008
- EGFR, p16, HPV Titer, Bcl-xL and p53, Sex, and Smoking As Indicators of Response to Therapy and Survival in Oropharyngeal CancerJournal of Clinical Oncology, 2008
- Response to Therapy and Outcomes in Oropharyngeal Cancer Are Associated With Biomarkers Including Human Papillomavirus, Epidermal Growth Factor Receptor, Gender, and SmokingInternational Journal of Radiation Oncology*Biology*Physics, 2007
- Identification of biomarkers that distinguish human papillomavirus (HPV)-positive versus HPV-negative head and neck cancers in a mouse modelProceedings of the National Academy of Sciences, 2006
- Overexpression of p16INK4 is a reliable marker of human papillomavirus–induced oral high-grade squamous dysplasiaOral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology, 2006
- Vertical transmission of the human papillomavirus: a systematic quantitative reviewCadernos de Saude Publica, 2005
- Human Papillomavirus (HPV) Transcripts in Malignant Inverted Papilloma are from Integrated HPV DNAThe Laryngoscope, 2005
- Transmission of High-Risk Human Papillomavirus (HPV) between Parents and Infant: a Prospective Study of HPV in Families in FinlandJournal of Clinical Microbiology, 2005
- Epidemiologic Classification of Human Papillomavirus Types Associated with Cervical CancerNew England Journal of Medicine, 2003
- Perinatal Transmission of Human Papillomavirus in Infants: Relationship Between Infection Rate and Mode of DeliveryObstetrics & Gynecology, 1998