Clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells
Open Access
- 29 June 2010
- journal article
- review article
- Published by Springer Science and Business Media LLC in Stem Cell Research & Therapy
- Vol. 1 (2), 19
- https://doi.org/10.1186/scrt19
Abstract
Adipose tissue is now recognized as an accessible, abundant, and reliable site for the isolation of adult stem cells suitable for tissue engineering and regenerative medicine applications. The past decade has witnessed an explosion of preclinical data relating to the isolation, characterization, cryopreservation, differentiation, and transplantation of freshly isolated stromal vascular fraction cells and adherent, culture-expanded, adipose-derived stromal/stem cells in vitro and in animal models. This body of work has provided evidence supporting clinical translational applications of adipose-derived cells in safety and efficacy trials. The present article reviews the case reports and phase I-III clinical evidence using autologous adipose-derived cells that have been published, to date, in the fields of gastroenterology, neurology, orthopedics, reconstructive surgery, and related clinical disciplines. Future directions and challenges facing the field are discussed and evaluated.Keywords
This publication has 91 references indexed in Scilit:
- Acceleration of spinal fusion using syngeneic and allogeneic adult adipose derived stem cells in a rat modelJournal of Orthopaedic Research, 2009
- Characterization of adipose tissue-derived cells isolated with the Celution™ systemCytotherapy, 2008
- Direct Comparison of Human Mesenchymal Stem Cells Derived from Adipose Tissues and Bone Marrow in Mediating Neovascularization in Response to Vascular IschemiaCellular Physiology and Biochemistry, 2007
- Clinical Treatment of Radiotherapy Tissue Damage by Lipoaspirate Transplant: A Healing Process Mediated by Adipose-Derived Adult Stem CellsPlastic and Reconstructive Surgery, 2007
- Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarctionNature Medicine, 2006
- Secretion of Angiogenic and Antiapoptotic Factors by Human Adipose Stromal CellsCirculation, 2004
- Adipose tissue engineering based on human preadipocytes combined with gelatin microspheres containing basic fibroblast growth factorBiomaterials, 2003
- De novo adipogenesis in mice at the site of injection of basement membrane and basic fibroblast growth factorProceedings of the National Academy of Sciences of the United States of America, 1998
- The function of adipocytes in the bone marrow stroma: an updateBone, 1996
- Free Autogenous Pearl Fat Grafts in the Face-A Preliminary Report of a Rediscovered TechniqueAnnals of Plastic Surgery, 1986