Is Spreading Depolarization Characterized by an Abrupt, Massive Release of Gibbs Free Energy from the Human Brain Cortex?
- 24 July 2012
- journal article
- research article
- Published by SAGE Publications in The Neuroscientist
- Vol. 19 (1), 25-42
- https://doi.org/10.1177/1073858412453340
Abstract
In the evolution of the cerebral cortex, the sophisticated organization in a steady state far away from thermodynamic equilibrium has produced the side effect of two fundamental pathological network events: ictal epileptic activity and spreading depolarization. Ictal epileptic activity describes the partial disruption, and spreading depolarization describes the near-complete disruption of the physiological double Gibbs–Donnan steady state. The occurrence of ictal epileptic activity in patients has been known for decades. Recently, unequivocal electrophysiological evidence has been found in patients that spreading depolarizations occur abundantly in stroke and brain trauma. The authors propose that the ion changes can be taken to estimate relative changes in Gibbs free energy from state to state. The calculations suggest that in transitions from the physiological state to ictal epileptic activity to spreading depolarization to death, the cortex releases Gibbs free energy in a stepwise fashion. Spreading depolarization thus appears as a twilight state close to death. Consistently, electrocorticographic recordings in the core of focal ischemia or after cardiac arrest display a smooth transition from the initial spreading depolarization component to the later ultraslow negative potential, which is assumed to reflect processes in cellular death.Keywords
This publication has 83 references indexed in Scilit:
- Correlates of spreading depolarization in human scalp electroencephalographyBrain, 2012
- Migraine Mutations Increase Stroke Vulnerability by Facilitating Ischemic DepolarizationsCirculation, 2012
- Spreading convulsions, spreading depolarization and epileptogenesis in human cerebral cortexBrain, 2011
- Recurrent Spontaneous Spreading Depolarizations Facilitate Acute Dendritic Injury in the Ischemic PenumbraJournal of Neuroscience, 2010
- Spreading depolarizations cycle around and enlarge focal ischaemic brain lesionsBrain, 2010
- Migraine aura pathophysiology: the role of blood vessels and microembolisationThe Lancet Neurology, 2010
- Experimental and Preliminary Clinical Evidence of an Ischemic Zone with Prolonged Negative DC Shifts Surrounded by a Normally Perfused Tissue Belt with Persistent Electrocorticographic DepressionJournal of Cerebral Blood Flow & Metabolism, 2010
- Cortical spreading ischaemia is a novel process involved in ischaemic damage in patients with aneurysmal subarachnoid haemorrhageBrain, 2009
- Association of seizures with cortical spreading depression and peri-infarct depolarisations in the acutely injured human brainClinical Neurophysiology, 2008
- Real‐time passive volume responses of astrocytes to acute osmotic and ischemic stress in cortical slices and in vivo revealed by two‐photon microscopyGlia, 2008