Expression pattern of adhesion molecules (E‐cadherin, α‐, β‐, γ‐catenin and claudin‐7), their influence on survival in primary breast carcinoma, and their corresponding axillary lymph node metastasis
- 8 January 2007
- Vol. 115 (1), 52-65
- https://doi.org/10.1111/j.1600-0463.2007.apm_524.x
Abstract
Reduced intercellular adhesion is implicated in the development of metastasis. This study investigates the expression of intercellular adhesion molecules (E-cadherin, alpha-, beta-, gamma-catenin and claudin-7) and their influence on survival in primary breast carcinomas and corresponding axillary lymph node metastases (ALNM), and evaluates associations between them and with clinicopathological factors. The expression of adhesion molecules was analyzed immunohistochemically in tissues from 196 patients with primary invasive breast carcinomas and their nodal metastases (174 ductal and 22 lobular types). The expression was evaluated using semi-quantitative scoring of the intensity and proportion of immunoreactivity. All five adhesion proteins showed significantly reduced expression in primary ductal carcinomas with re-expression in ALNM (p<0.001). In uni- and multivariate analyses, the expression of E-cadherin in the primary tumours was a significant predictor of disease-free survival and distant disease-free survival. Thus, abnormal E-cadherin expression in the primary invasive breast carcinoma seems to be an independent prognostic biomarker in predicting a shorter survival in node-positive breast cancer patients. The results indicate that abnormal expression of the adhesion molecules in the primary tumours with re-expression in corresponding nodal metastases is a common event in breast ductal carcinomas and may play a central role in establishing metastasis.Keywords
This publication has 39 references indexed in Scilit:
- Cancer Invasion and MetastasisOncology, 2005
- Automated Quantitative Analysis of E-Cadherin Expression in Lymph Node Metastases Is Predictive of Survival in Invasive Ductal Breast CancerClinical Cancer Research, 2005
- E‐cadherin expression in invasive non‐lobular carcinoma of the breast and its prognostic significanceHistopathology, 2005
- β-Catenin and Plakoglobin N- and C-tails Determine Ligand SpecificityPublished by Elsevier BV ,2004
- Sticky BusinessCell, 2003
- Expression patterns of β-catenin in in situ and invasive breast cancerEuropean Journal of Surgical Oncology, 2001
- Differential Expression of E-Cadherin in Lobular and Ductal Neoplasms of the Breast and Its Biologic and Diagnostic ImplicationsAmerican Journal of Clinical Pathology, 2001
- Altered expression of E-cadherin in breast cancerEuropean Journal Of Cancer, 2000
- pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long‐term follow‐upHistopathology, 1991
- Cadherin Cell Adhesion Receptors as a Morphogenetic RegulatorScience, 1991