Paxillin expression levels are correlated with clinical stage and metastasis in salivary adenoid cystic carcinoma
- 1 January 2010
- journal article
- research article
- Published by Wiley in Journal of Oral Pathology & Medicine
- Vol. 39 (7), 548-551
- https://doi.org/10.1111/j.1600-0714.2009.00859.x
Abstract
To investigate the relationship between paxillin expression and clinicopathological features and metastasis in salivary adenoid cystic carcinoma (SACC). A total of 47 SACC were assessed histochemically for paxillin expression. Paxillin immunoreactivity was compared with histological type, clinical stage and distant metastasis. Paxillin expression was identified in 57.45% of SACC as cytoplasmic staining and the expression was correlated with distant metastasis and clinical stage (P < 0.05), but not with histological type. Our observations indicate that paxillin expression is upregulated in SACC. High expression of paxillin was correlated with a more advanced stage and metastasis in SACC, suggesting that paxillin is a disease marker in advanced SACC and SACC with distant metastasis, and, consequently, may have value as a therapeutic target for SACC.Keywords
This publication has 16 references indexed in Scilit:
- Cell migration to the chemokine CXCL8: Paxillin is activated and regulates adhesion and cell motilityCellular and Molecular Life Sciences, 2009
- Pressure activates colon cancer cell adhesion via paxillin phosphorylation, Crk, Cas, and Rac1Cellular and Molecular Life Sciences, 2008
- Immunohistochemical detection of platelet-derived endothelial cell growth factor/thymidine phosphorylase and angiopoietins in ameloblastic tumorsJournal of Oral Pathology & Medicine, 2006
- Salivary gland adenoid cystic carcinoma: A review of chemotherapy and molecular therapiesOral Oncology, 2006
- Brk Activates Rac1 and Promotes Cell Migration and Invasion by Phosphorylating PaxillinMolecular and Cellular Biology, 2004
- Tyrosine phosphorylation of paxillin FAK AND p130CAS effects on cell spreading and migrationFrontiers in Bioscience-Landmark, 2002
- Multiple stimuli induce tyrosine phosphorylation of the Crk-binding sites of paxillinBiochemical Journal, 2001
- Paxillin: a focal adhesion-associated adaptor proteinOncogene, 2001
- Phosphorylation of Tyrosine Residues 31 and 118 on Paxillin Regulates Cell Migration through an Association with Crk in Nbt-II CellsThe Journal of cell biology, 2000
- Renal cell carcinomaCancer, 1997