Expression of Interleukin-10 Activity by Epstein-Barr Virus Protein BCRF1
- 9 November 1990
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 250 (4982), 830-832
- https://doi.org/10.1126/science.2173142
Abstract
Cytokine synthesis inhibitory factor (CSIF; interleukin-10), a product of mouse TH2 T cell clones that inhibits synthesis of cytokines by mouse TH1 T cell clones, exhibits extensive sequence similarity to an uncharacterized open reading frame in the Epstein-Barr virus BCRF1. Recombinant BCRF1 protein mimics the activity of interleukin-10, suggesting that BCRF1 may have a role in the interaction of the virus with the host's immune system.Keywords
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