Sex and hormonal influences on seizures and epilepsy
- 28 February 2013
- journal article
- review article
- Published by Elsevier BV in Hormones and Behavior
- Vol. 63 (2), 267-277
- https://doi.org/10.1016/j.yhbeh.2012.03.018
Abstract
This article is part of a Special Issue "Hormones & Neurotrauma". Epilepsy is the third most common chronic neurological disorder. Clinical and experimental evidence supports the role of sex and influence of sex hormones on seizures and epilepsy as well as alterations of the endocrine system and levels of sex hormones by epileptiform activity. Conversely, seizures are sensitive to changes in sex hormone levels, which in turn may affect the seizure-induced neuronal damage. The effects of reproductive hormones on neuronal excitability and seizure-induced damage are complex to contradictory and depend on different mechanisms, which have to be accounted for in data interpretation. Both estradiol and progesterone/allopregnanolone may have beneficial effects for patients with epilepsy. Individualized hormonal therapy should be considered as adjunctive treatment in patients with epilepsy to improve seizure control as well as quality of life.Keywords
Funding Information
- National Institutes of Health (NS056093)
This publication has 179 references indexed in Scilit:
- Post-weaning social isolation of female rats, anxiety-related behavior, and serotonergic systemsBrain Research, 2012
- Type 1 5α-reductase may be required for estrous cycle changes in affective behaviors of female miceBehavioural Brain Research, 2012
- NeurosteroidsArts and The Brain: Psychology and Physiology Beyond Pleasure, 2010
- Progesterone, administered before kainic acid, prevents decrements in cognitive performance in the Morris Water MazeDevelopmental Neurobiology, 2010
- Teratogenic Effects of Antiepileptic MedicationsNeurologic Clinics, 2009
- Estrogen action: A historic perspective on the implications of considering alternative approachesPhysiology & Behavior, 2009
- The role of neurosteroids in the pathophysiology and treatment of catamenial epilepsyEpilepsy Research, 2009
- Neurosteroid Replacement Therapy for Catamenial EpilepsyNeurotherapeutics, 2009
- Seizures and reproductive function: Insights from female rats with epilepsyAnnals of Neurology, 2008
- Brain microglia express steroid-converting enzymes in the mouseThe Journal of Steroid Biochemistry and Molecular Biology, 2008