Thioridazine: a selective inhibitor of peroxisomal β‐oxidation in vivo
- 5 August 1985
- journal article
- Published by Wiley in FEBS Letters
- Vol. 187 (2), 331-333
- https://doi.org/10.1016/0014-5793(85)81270-9
Abstract
In vivo administration of the phenothiazine drug, thioridazine, inhibits hepatic peroxisomal β-oxidation in mice. In starving animals, 3-hydroxybutyrate concentration is not decreased by thioridazine treatment. These results provide the first demonstration of thioridazine as a selective inhibitor of peroxisomal β-oxidation in intact animals. Thioridazine might supply a tool for simulation of pathological conditions in which peroxisomal β-oxidation is impaired.Keywords
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