Polyketide-derived fungal metabolites from Bipolaris sorokiniana and their significance in the biosynthesis of sterigmatocystin and aflatoxin B1

Abstract

The metabolites averufin, versiconol, versiconal acetate, versiconol acetate, versicolorin C, sterigmatocystin, and a new metabolite, 3,8-dihydroxy-4-(2,3-dihydroxy-1-hydroxymethylpropyl)-1-methoxyxanthone were isolated from cultures of Bipolaris sorokiniana. Evidence is presented for the reformulation of bipolarin as versiconol. The biosynthetic implications of the natural occurrence of versiconal acetate and of versiconol acetate are discussed.