Signaling Vascular Morphogenesis and Maintenance
- 4 July 1997
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 277 (5322), 48-50
- https://doi.org/10.1126/science.277.5322.48
Abstract
Douglas Hanahan Blood vessels are formed and maintained by a family of soluble factors that interact with tyrosine kinase receptors on the endothelial cell surface. A new angiogenesis factor (Ang2) is reported in an article by Maisonpierre et al. in this week9s issue. Hanahan describes what is known about the process of vascular morphogenesis and maintenance and how this new factor fits into this complex regulatory system.Keywords
This publication has 15 references indexed in Scilit:
- Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo AngiogenesisScience, 1997
- Mechanisms of angiogenesisNature, 1997
- Vascular System Defects and Impaired Cell Chemokinesis as a Result of Gα 13 DeficiencyScience, 1997
- Blood Vessel Formation: What Is Its Molecular Basis?Cell, 1996
- Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression CloningCell, 1996
- VasculogenesisAnnual Review of Cell and Developmental Biology, 1995
- Requirement for neuregulin receptor erbB2 in neural and cardiac developmentNature, 1995
- Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formationNature, 1995
- Failure of blood-island formation and vasculogenesis in Flk-1-deficient miceNature, 1995
- Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo.Genes & Development, 1994