Frontotemporal dementia: Clinicopathological correlations
Top Cited Papers
- 22 May 2006
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 59 (6), 952-962
- https://doi.org/10.1002/ana.20873
Abstract
Objective Frontotemporal lobar degeneration (FTLD) is characterized by impairments in social, behavioral, and/or language function, but postmortem studies indicate that multiple neuropathological entities lead to FTLD. This study assessed whether specific clinical features predict the underlying pathology. Methods A clinicopathological correlation was performed on 90 consecutive patients with a pathological diagnosis of frontotemporal dementia and was compared with an additional 24 cases accrued during the same time period with a clinical diagnosis of FTLD, but with pathology not typically associated with frontotemporal dementia. Results Postmortem examination showed multiple pathologies including tauopathies (46%), FTLD with ubiquitin‐positive inclusions (29%), and Alzheimer's disease (17%). The pathological groups manifested some distinct demographic, clinical, and neuropsychological features, although these attributes showed only a statistical association with the underlying pathology. FTLD with ubiquitin‐positive inclusions was more likely to present with both social and language dysfunction, and motor neuron disease was more likely to emerge in these patients. Tauopathies were more commonly associated with an extrapyramidal disorder. Alzheimer's disease was associated with relatively greater deficits in memory and executive function. Interpretation Clinical and neuropsychological features contribute to delineating the spectrum of pathology underlying a patient diagnosed with FTLD, but biomarkers are needed that, together with the clinical phenotype, can predict the underlying neuropathology. Ann Neurol 2006;59:952‐962Keywords
This publication has 49 references indexed in Scilit:
- Cerebrospinal fluid profile in frontotemporal dementia and Alzheimer's diseaseAnnals of Neurology, 2005
- Antemortem diagnosis of frontotemporal lobar degenerationAnnals of Neurology, 2005
- Clinicopathological correlates in frontotemporal dementiaAnnals of Neurology, 2004
- Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing proteinNature Genetics, 2004
- Primary Progressive Aphasia: A ReviewNeurocase, 2004
- Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset FamiliesScience, 1993
- Semantic and perceptual errors in aphasics' freehand category drawing.Neuropsychology, 1993
- SEMANTIC DEMENTIABrain, 1992
- New ubiquitin-positive intraneuronal inclusions in the extra-motor cortices in patients with amyotrophic lateral sclerosisNeuroscience Letters, 1991
- Frontal lobe degeneration of non-Alzheimer type. I. NeuropathologyArchives of Gerontology and Geriatrics, 1987