Light-Responsive Polyelectrolyte/Gold Nanoparticle Microcapsules
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- 26 January 2005
- journal article
- Published by American Chemical Society (ACS) in The Journal of Physical Chemistry B
- Vol. 109 (7), 3071-3076
- https://doi.org/10.1021/jp045070x
Abstract
We report the preparation and characterization of light-responsive delivery vehicles, microcapsules composed of multiple polyelectrolyte layers and light-absorbing gold nanoparticles. The nanostructured capsules were loaded with macromolecules (fluorescein isothiocyanate-labeled dextran) by exploiting the pH-dependence of the shell permeability, and the encapsulated material was released on demand upon irradiation with short (10 ns) laser pulses in the near-infrared (1064 nm). In addition, the polyelectrolyte multilayer shell was modified with lipids (dilauroylphosphatidylethanolamine) and then functionalized with ligands (monoclonal immunoglobulin G antibodies) for the purposes of enhanced stability and targeted delivery, respectively. We anticipate that these capsules will find application in a range of areas where controlled delivery is desirable.Keywords
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