High dose concentration administration of ascorbic acid inhibits tumor growth in BALB/C mice implanted with sarcoma 180 cancer cells via the restriction of angiogenesis
Open Access
- 11 August 2009
- journal article
- Published by Springer Science and Business Media LLC in Journal of Translational Medicine
- Vol. 7 (1), 70
- https://doi.org/10.1186/1479-5876-7-70
Abstract
To test the carcinostatic effects of ascorbic acid, we challenged the mice of seven experimental groups with 1.7 × 10-4 mol high dose concentration ascorbic acid after intraperitoneal administrating them with sarcoma S-180 cells. The survival rate was increased by 20% in the group that received high dose concentration ascorbic acid, compared to the control. The highest survival rate was observed in the group in which 1.7 × 10-4 mol ascorbic acid had been continuously injected before and after the induction of cancer cells, rather than just after the induction of cancer cells. The expression of three angiogenesis-related genes was inhibited by 0.3 times in bFGF, 7 times in VEGF and 4 times in MMP2 of the groups with higher survival rates. Biopsy Results, gene expression studies, and wound healing analysis in vivo and in vitro suggested that the carcinostatic effect induced by high dose concentration ascorbic acid occurred through inhibition of angiogenesis.This publication has 43 references indexed in Scilit:
- Proteomic analysis reveals upregulation of RKIP in S‐180 implanted BALB/C mouse after treatment with ascorbic acidJournal of Cellular Biochemistry, 2009
- Annual Report to the Nation on the Status of Cancer, 1975–2005, Featuring Trends in Lung Cancer, Tobacco Use, and Tobacco ControlJNCI Journal of the National Cancer Institute, 2008
- Anti-angiogenic effect of high doses of ascorbic acidJournal of Translational Medicine, 2008
- Vitamin C and cancer revisitedProceedings of the National Academy of Sciences of the United States of America, 2008
- Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivoProceedings of the National Academy of Sciences of the United States of America, 2007
- Orthomolecular Oncology Review: Ascorbic Acid and Cancer 25 Years LaterIntegrative Cancer Therapies, 2005
- Scratching below the Surface: Wound Healing and Alanine Mutagenesis Provide Unique Insights into Interactions between Eristostatin, Platelets and Melanoma CellsPathophysiology of Haemostasis and Thrombosis, 2005
- Basic fibroblast growth factor and ovarian cancerThe Journal of Steroid Biochemistry and Molecular Biology, 1995
- Basic Fibroblast Growth Factor and Receptor Expression in Human Ovarian CancerGynecologic Oncology, 1994
- Tumor Angiogenesis: Therapeutic ImplicationsThe New England Journal of Medicine, 1971