Distinct pharmacology and metabolism of K2 synthetic cannabinoids compared to Δ9-THC: Mechanism underlying greater toxicity?
- 29 September 2013
- journal article
- research article
- Published by Elsevier BV in Life Sciences
- Vol. 97 (1), 45-54
- https://doi.org/10.1016/j.lfs.2013.09.017
Abstract
No abstract availableKeywords
This publication has 116 references indexed in Scilit:
- Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activityBiochemical Pharmacology, 2012
- A survey study to characterize use of Spice products (synthetic cannabinoids)Drug and Alcohol Dependence, 2012
- Cannabinergic aminoalkylindoles, including AM678=JWH018 found in ‘Spice’, examined using drug (Δ9-tetrahydrocannabinol) discrimination for ratsBehavioural Pharmacology, 2011
- Brain cannabinoid CB2 receptors modulate cocaine's actions in miceNature Neuroscience, 2011
- Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in chronic daily cannabis smokersMolecular Psychiatry, 2011
- Solid-Phase Extraction and Quantitative Measurement of Omega and Omega-1 Metabolites of JWH-018 and JWH-073 in Human UrineAnalytical Chemistry, 2011
- Quantitative Measurement of JWH-018 and JWH-073 Metabolites Excreted in Human UrineAnalytical Chemistry, 2011
- CP47,497-C8 and JWH073, commonly found in ‘Spice’ herbal blends, are potent and efficacious CB1 cannabinoid receptor agonistsEuropean Journal of Pharmacology, 2011
- Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940Bioorganic & Medicinal Chemistry, 2008
- The behavioral pharmacology of hallucinogensBiochemical Pharmacology, 2008