Mathematical models of energy homeostasis
- 8 July 2008
- journal article
- review article
- Published by The Royal Society in Journal of The Royal Society Interface
- Vol. 5 (27), 1119-1135
- https://doi.org/10.1098/rsif.2008.0216
Abstract
Diabetes and obesity present a mounting global challenge. Clinicians are increasingly turning to mechanism-based mathematical models for a quantitative definition of physiological defects such as insulin resistance, glucose intolerance and elevated obesity set points, and for predictions of the likely outcomes of therapeutic interventions. However, a very large range of such models is available, making a judicious choice difficult. To better inform this choice, here we present the most important models published to date in a uniform format, discussing similarities and differences in terms of the decisions faced by modellers. We review models for glucostasis, based on the glucose–insulin feedback control loop, and consider extensions to long-term energy balance, dislipidaemia and obesity.Keywords
This publication has 88 references indexed in Scilit:
- From empirical patterns to theory: a formal metabolic theory of lifePhilosophical Transactions Of The Royal Society B-Biological Sciences, 2008
- Insulin receptors in β-cells are critical for islet compensatory growth response to insulin resistanceProceedings of the National Academy of Sciences of the United States of America, 2007
- Modeling the glucose–insulin regulatory system and ultradian insulin secretory oscillations with two explicit time delaysJournal of Theoretical Biology, 2006
- A critical review of mathematical models and data used in diabetologyBioMedical Engineering OnLine, 2006
- Modeling the Insulin–Glucose Feedback System: The Significance of Pulsatile Insulin SecretionJournal of Theoretical Biology, 2000
- A Model of β -Cell Mass, Insulin, and Glucose Kinetics: Pathways to DiabetesJournal of Theoretical Biology, 2000
- Altered function of insulin receptor substrate-1–deficient mouse islets and cultured β-cell linesJCI Insight, 1999
- STRUCTURE AND FUNCTION OF HEXOSE TRANSPORTERSAnnual Review of Biochemistry, 1991
- Glycemic thresholds for activation of glucose counterregulatory systems are higher than the threshold for symptoms.JCI Insight, 1987
- THE GLUCOSE FATTY-ACID CYCLE ITS ROLE IN INSULIN SENSITIVITY AND THE METABOLIC DISTURBANCES OF DIABETES MELLITUSThe Lancet, 1963