Complete Genome Sequence of Central Africa Human T-Cell Lymphotropic Virus Subtype 1b
- 15 November 2012
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 86 (22), 12451
- https://doi.org/10.1128/jvi.02258-12
Abstract
Human T-lymphotropic virus type 1 (HTLV-1) has a global spread, and it is estimated that around 20 million persons are infected. Seven major genetic subtypes are recognized. However, there are complete genomes only from the HTLV-1a (cosmopolitan) and HTLV-1c (Melanesian) subtypes. Here, the first full-length genome of an HTLV-1b strain, a subtype so far restricted to Central African countries, is revealed. The genome size of HTLV-1b SF26, a strain isolated in Brazil, was determined to be 8,267 bp. The genomic analysis showed that all characteristic regions and genes of a prototypic HTLV-1 virus are conserved. This genome can provide information for further studies on the evolutionary history and pathogenic potential of this human oncovirus.This publication has 4 references indexed in Scilit:
- Emergence of unique primate T-lymphotropic viruses among central African bushmeat huntersProceedings of the National Academy of Sciences of the United States of America, 2005
- Human T‐cell‐leukemia virus type I in post‐transfusional spastic paraparesis: Complete proviral sequence from uncultured blood cellsInternational Journal of Cancer, 1995
- Molecular cloning and analysis of a new variant of human T‐cell leukemia virus (HTLV‐Ib) from an African patient with adult T‐cell leukemia‐lymphomaInternational Journal of Cancer, 1984
- Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphomaProceedings of the National Academy of Sciences of the United States of America, 1980