Gd(DOTA): An alternative to Gd(DTPA) as a T1,2 relaxation agent for NMR imaging or spectroscopy
- 1 October 1986
- journal article
- research article
- Published by Wiley in Magnetic Resonance in Medicine
- Vol. 3 (5), 808-812
- https://doi.org/10.1002/mrm.1910030517
Abstract
Methods have been devised for obtaining gadolinium(III) complexes of the ligands NOTA (1, 4, 7-triazacyclononane-N, N′, N″-triacetic acid), DOTA (1, 4, 7, 10-tetraazacyclododecane-N, N′, N″, N‴-tetraacetic acid), TETA (1,4,8,11-tetraazacyclotetradecane-N, N′, N″, N‴-tetraacetic acid), and DTPA (diethylenetriaminepentaacetic acid) as solids for use as pharmaceuticals. Their effectiveness as in vitro and in vivo contrast agents for NMR imaging or T1,2 relaxation agents for spectroscopy has been investigated. The Gd(DOTA) complex was shown to be a more stable alternative to Gd(DTPA) by serum stability studies and measurement of stability constants. Images of tumors grown in athymic mice were obtained by NMR after injection of Gd(DOTA) and Gd(DTPA). © 1986 Academic Press, Inc.This publication has 15 references indexed in Scilit:
- Dissociation kinetics of 1,7-diaza-4,10-,13-trioxacyclopentadecane-N,N'-diacetic acid complexes of lanthanidesInorganic Chemistry, 1986
- Magnetic field dependence of solvent proton relaxation rates induced by Gd3+ and Mn2+ complexes of various polyaza macrocyclic ligands: Implications for NMR imagingMagnetic Resonance in Medicine, 1986
- INTRAVENOUS CHELATED GADOLINIUM AS A CONTRAST AGENT IN NMR IMAGING OF CEREBRAL TUMOURSThe Lancet, 1984
- Metal complex formation with 1,10-diaza-4,7,13,16-tetraoxacyclooctadecane-N,N'-diacetic acid. An approach to potential lanthanide ion selective reagentsInorganic Chemistry, 1983
- BEST — A new program for rigorous calculation of equilibrium parameters of complex multicomponent systemsCanadian Journal of Chemistry, 1982
- Nuclear analogs of β-lactam antibiotics. XIV. Synthesis of penems via (4-tritylthio-2-azetidinon-1-yl)triphenylphosphoranylideneacetatesCanadian Journal of Chemistry, 1982
- Tumor Imaging with Radioactive Metal Chelates Conjugated to Monoclonal AntibodiesScience, 1982
- Nuclear magnetic resonance spectroscopy of lanthanide complexes with a tetraacetic tetraaza macrocycle. Unusual conformation propertiesInorganic Chemistry, 1980
- Aqueous complexes of gallium(III)Inorganic Chemistry, 1976
- Observations on the rare earths—LXXV(1): The stabilities of diethylenetriaminepentaacetic acid chelatesJournal of Inorganic and Nuclear Chemistry, 1962