Burden of multimorbidity and polypharmacy among cancer survivors: a population-based nested case-control study
- 1 February 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Supportive Care in Cancer
- Vol. 29 (2), 713-723
- https://doi.org/10.1007/s00520-020-05529-3
Abstract
Purpose Individuals living with cancer have been shown to have a higher burden of comorbid disease and multimorbidity in comparison to their cancer-free counterparts consequently, leaving them at risk of polypharmacy (i.e., >= 5 medications) and its potential negative effects. The primary aim of the current study was to examine the self-reported prevalence of and association between multimorbidity and prescription medication use in a population-based sample of adult cancer survivors (CS). Methods This retrospective, nested case-control study drew participant data from the Atlantic Partnership for Tomorrow's Health cohort. CS (n = 1708) were matched to 4 non-cancer controls (n = 6832) by age and sex. Prevalence of polypharmacy by number of chronic conditions and age was estimated with 95% CI. Logistic regression was used to examine the association between multimorbidity and polypharmacy while adjusting for sociodemographic and lifestyle factors. The comorbidity-polypharmacy score was also calculated as an estimate of disease burden. Results Multimorbidity was common in both CS (53%) and non-cancer controls (43%); however, a significantly higher percentage of CS reported multimorbidity (p < 0.001). Prescription medication use was also found to be significantly higher among CS (2.3 +/- 2.6) compared to non-cancer controls (1.8 +/- 2.3; p < 0.0001). Exploratory comorbidity-polypharmacy score analyses indicated that CS had a significantly higher overall disease burden than the age/sex-matched non-cancer controls. Conclusions As CS appear to be at a higher risk of multimorbidity and polypharmacy and by extension, increased healthcare burden, ongoing education on the prevention of medication-related harm, and interventions to reduce the occurrence of both co-morbid disease and unnecessary medications are warranted.Keywords
Funding Information
- Canadian Partnership Against Cancer (N/A)
- Health Canada (N/A)
This publication has 44 references indexed in Scilit:
- Association between anxiety, depression, and comorbid chronic diseases among cancer survivorsPsycho‐Oncology, 2019
- Impact of Comorbidities on Survival in Gastric, Colorectal, and Lung Cancer PatientsJournal of Epidemiology, 2019
- Cancer SurvivorshipNew England Journal of Medicine, 2018
- Comparison of Comorbid Conditions Between Cancer Survivors and Age-Matched Patients Without CancerJournal of Clinical Medicine Research, 2018
- Comorbidity, physical and mental health among cancer patients and survivors: An Australian population‐based studyAsia-Pacific Journal of Clinical Oncology, 2017
- Anticipating the “Silver Tsunami”: Prevalence Trajectories and Co-Morbidity Burden among Older Cancer Survivors in the United StatesCancer Epidemiology, Biomarkers & Prevention, 2016
- Differences in chronic conditions and lifestyle behaviour between people with a history of cancer and matched controlsThe Medical Journal of Australia, 2014
- The impact of comorbidity on cancer survival: a reviewClinical Epidemiology, 2013
- The impact of comorbidity on Health-Related Quality of Life among cancer survivors: analyses of data from the PROFILES registryJournal of Cancer Survivorship, 2013
- Cancer as a chronic diseaseCollegian, 2010