Clinical Trial of Doxycycline for Matrix Metalloproteinase-9 Inhibition in Patients With an Abdominal Aneurysm
- 28 April 2009
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Circulation
- Vol. 119 (16), 2209-2216
- https://doi.org/10.1161/circulationaha.108.806505
Abstract
Background— Doxycycline has been shown to effectively inhibit aneurysm formation in animal models of abdominal aortic aneurysm. Although this effect is ascribed to matrix metalloproteinase-9 inhibition, such an effect is unclear in human studies. We reevaluated the effect of doxycycline on aortic wall protease content in a clinical trial and found that doxycycline selectively reduces neutrophil-derived proteases. We thus hypothesized that doxycycline acts through an effect on vascular inflammation.Keywords
This publication has 35 references indexed in Scilit:
- Enhanced expression and activation of pro-inflammatory transcription factors distinguish aneurysmal from atherosclerotic aorta: IL-6- and IL-8-dominated inflammatory responses prevail in the human aneurysmClinical Science, 2008
- Collagen Degradation in the Abdominal Aneurysm: A Conspiracy of Matrix Metalloproteinase and Cysteine CollagenasesThe American Journal of Pathology, 2007
- Critical role of dipeptidyl peptidase I in neutrophil recruitment during the development of experimental abdominal aortic aneurysmsProceedings of the National Academy of Sciences, 2007
- Pathophysiology Defined by Altered Signal Transduction Pathways: The Role of JAK-STAT and PI3K Signaling in Leukemic Large Granular LymphocytesCell Cycle, 2006
- Tetracyclines: Nonantibiotic properties and their clinical implicationsJournal of the American Academy of Dermatology, 2006
- Safety of doxycycline and minocycline: A systematic reviewClinical Therapeutics, 2005
- High Prevalence of Circulating CD4+CD28−T-Cells in Patients With Small Abdominal Aortic AneurysmsArteriosclerosis, Thrombosis, and Vascular Biology, 2005
- Reduction of the aortic inflammatory response in spontaneous atherosclerosis by blockade of macrophage migration inhibitory factor (MIF)Atherosclerosis, 2005
- Molecular cloning of cDNA and a chromosomal gene encoding GPE1‐BP, a nuclear protein which binds to granulocyte colony‐stimulating factor promoter element 1FEBS Letters, 1991
- In vivo suppression of neutrophil chemotaxis by systemically and topically administered tetracyclineJournal of the American Academy of Dermatology, 1983