The Gut-Brain Axis: The Missing Link in Depression
Open Access
- 31 December 2015
- journal article
- Published by Korean College of Neuropsychopharmacology in Clinical Psychopharmacology and Neuroscience
- Vol. 13 (3), 239-244
- https://doi.org/10.9758/cpn.2015.13.3.239
Abstract
The gut microbiota is essential to human health and the immune system and plays a major role in the bidirectional communication between the gut and the brain. Based on evidence, the gut microbiota is associated with metabolic disorders such as obesity, diabetes mellitus and neuropsychiatric disorders such as schizophrenia, autistic disorders, anxiety disorders and major depressive disorders. In the past few years, neuroscientific research has shown the importance of the microbiota in the development of brain systems. Recent studies showed that the microbiota could activate the immune and central nervous systems, including commensal and pathogenic microorganisms in the gastrointestinal tract. Gut microorganisms are capable of producing and delivering neuroactive substances such as serotonin and gamma-aminobutyric acid, which act on the gut-brain axis. Preclinical research in rodents suggested that certain probiotics have antidepressant and anxiolytic activities. Effects may be mediated via the immune system or neuroendocrine systems. Herein, we present the latest literature examining the effects of the gut microbiota on depression.Keywords
This publication has 76 references indexed in Scilit:
- The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43Nature Communications, 2013
- Diversity, stability and resilience of the human gut microbiotaNature, 2012
- Neurobehavioral Effects of Interferon-α in Patients with Hepatitis-C: Symptom Dimensions and Responsiveness to ParoxetineNeuropsychopharmacology, 2012
- Enhanced peripheral toll-like receptor responses in psychosis: further evidence of a pro-inflammatory phenotypeTranslational Psychiatry, 2011
- Normal gut microbiota modulates brain development and behaviorProceedings of the National Academy of Sciences of the United States of America, 2011
- Coordination of tolerogenic immune responses by the commensal microbiotaJournal of Autoimmunity, 2010
- Pattern Recognition Receptors and InflammationCell, 2010
- The endocannabinoid system links gut microbiota to adipogenesisMolecular Systems Biology, 2010
- Microbes in Gastrointestinal Health and DiseaseGastroenterology, 2009
- Mechanisms underlying the resistance to diet-induced obesity in germ-free miceProceedings of the National Academy of Sciences of the United States of America, 2007