HLA-DRB1*1502 allele, subtype of DR15, is associated with susceptibility to ulcerative colitis and its progression
- 1 April 1995
- journal article
- Published by Springer Science and Business Media LLC in Digestive Diseases and Sciences
- Vol. 40 (4), 814-818
- https://doi.org/10.1007/bf02064985
Abstract
HLA-DRB1 allele typing was performed by the PCR-RFLP method on 59 ulcerative colitis (UC) patients and 136 healthy controls. Phenotypic frequencies of HLA-B52 and DR2 were significantly increased among the UC patients, serologically. DNA typing of HLA-DRB1 revealed that the genotypic frequency of DRB1*1502 was higher in UC than in the controls (49.2% vs 17.6%;Pβ-chain (vs 51% of control;Pβ-chain and surrounding amino acid sequence of HLA-DRB1*1502 is strongly associated with susceptibility to UC.Keywords
This publication has 13 references indexed in Scilit:
- Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1Nature, 1993
- HLA‐DRβ chain residue 86 controls DRαβ dimer stabilityEuropean Journal of Immunology, 1993
- HLA class II alleles and susceptibility and resistance to insulin dependent diabetes mellitus in Mexican-American familiesNature Genetics, 1993
- Distinct associations of HLA Class II genes with inflammatory bowel diseaseGastroenterology, 1993
- Analysis of genes within the HLA region affecting susceptibility to ulcerative colitisHuman Immunology, 1993
- The set of naturally processed peptides displayed by DR molecules is tuned by polymorphism of residue 86European Journal of Immunology, 1993
- HLA‐DRB1 genotyping by modified PCR‐RFLP method combined with group‐specific primersTissue Antigens, 1992
- HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitusNature, 1987
- Association of the Human Lymphocyte-DR2 Antigen with Japanese Ulcerative ColitisGastroenterology, 1982