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Telomeres and essential hypertension
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Telomeres and essential hypertension
Telomeres and essential hypertension
Abraham Aviv
Abraham Aviv
HA
Hana Aviv
Hana Aviv
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1 April 1999
journal article
review article
Published by
Oxford University Press (OUP)
in
American Journal of Hypertension
Vol. 12
(4)
,
427-432
https://doi.org/10.1016/S0895-7061(98)00202-7
Abstract
The dynamics of telomere attrition in human beings might shape the course of age-dependent, complex genetic traits. One of these traits is essential hypertension. Age-dependent telomere attrition could lead to critically shortened telomeres and aneuploidy (ie, the loss or gain of chromosomes) with a resultant mosaicism that will be variably expressed in different cells and tissues. The chromosomal instability and loss of heterozygosity resulting from this process would promote an age-dependent expression of variant genes that harbor susceptibility for essential hypertension or genes that accelerate the process of aging. Am J Hypertens 1999;11:427–432 © 1999 American Journal of Hypertension, Ltd.
Keywords
COMPLEX TRAIT
GENETICS
ESSENTIAL HYPERTENSION
TELOMERE ATTRITION
ANEUPLOIDY
PHENOTYPE
GENETIC LINKAGE
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Cited by 20 articles