Idiopathic inflammatory myositis is associated with a high incidence of hypertension and diabetes mellitus
- 3 May 2010
- journal article
- Published by Wiley in International Journal of Rheumatic Diseases
- Vol. 13 (2), 132-137
- https://doi.org/10.1111/j.1756-185x.2010.01470.x
Abstract
AIMS: The long-terms complications of immunosuppressive and anti-inflammatory treatment in idiopathic inflammatory myositis (IIM) are unknown. We sought to determine the complications of these treatments in a large cohort of patients with biopsy-proven IIM. METHODS: A South Australian database for patients with biopsy-proven IIM was established. Clinical details of patients including treatment received were recorded. RESULTS: Forty-three patients with dermatomyositis (DM), 184 with polymyositis (PM) and 117 with inclusion body myositis (IBM) were registered on the database. The prevalence of hypertension and diabetes in this population was 62% and 29%, respectively, considerably higher than the background prevalence of 9.4% and 4%, making detection of treatment-related adverse effects difficult. Hypertension and ischemic heart disease were more likely to be present prior to the diagnosis of IIM rather than following it. Hypertension and diabetes occurred more frequently following the diagnosis of myositis, in patients with DM compared with PM or IBM. CONCLUSIONS: We report a novel association of IIM with hypertension, diabetes and ischemic heart disease, indicating that a comprehensive assessment of vascular risk factors is essential in IIM.Vidya S. Limaye, Sue Lester, Peter Blumbergs and Peter J. Roberts-ThomsoKeywords
This publication has 16 references indexed in Scilit:
- Muscle compromise in diabetesActa Radiologica, 2008
- Cardiovascular co-morbidity in rheumatic diseasesVascular Health and Risk Management, 2008
- Skeletal muscle insulin resistance: role of inflammatory cytokines and reactive oxygen speciesAmerican Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2008
- Use of oral corticosteroids and the risk of acute myocardial infarctionAtherosclerosis, 2007
- Prognosis and mortality of polymyositis and dermatomyositis patientsClinical Rheumatology, 2006
- Prevalence and Correlates of Accelerated Atherosclerosis in Systemic Lupus ErythematosusNew England Journal of Medicine, 2003
- Autoantibodies against the angiotensin receptor (AT1) in patients with hypertensionJournal Of Hypertension, 2000
- α 1 -Adrenergic Receptor Antibodies in Patients With Primary HypertensionHypertension, 1997
- INCLUSION BODY MYOSITISBrain, 1989
- Polymyositis and DermatomyositisNew England Journal of Medicine, 1975