Modeling the Flow Behavior and Flow Rate of Medium Viscosity Alginate for Scaffold Fabrication With a Three-Dimensional Bioplotter
- 20 April 2017
- journal article
- research article
- Published by ASME International in Journal of Manufacturing Science and Engineering
- Vol. 139 (8)
- https://doi.org/10.1115/1.4036226
Abstract
Tissue regeneration with scaffolds has proven promising for the repair of damaged tissues or organs. Dispensing-based printing techniques for scaffold fabrication have drawn considerable attention due to their ability to create complex structures layer-by-layer. When employing such printing techniques, the flow rate of the biomaterial dispensed from the needle tip is critical for creating the intended scaffold structure. The flow rate can be affected by a number of variables including the material flow behavior, temperature, needle geometry, and dispensing pressure. As such, model equations can play a vital role in the prediction and control of the flow rate of the material dispensed, thus facilitating optimal scaffold fabrication. This paper presents the development of a model to represent the flow rate of medium viscosity alginate dispensed for the purpose of scaffold fabrication, by taking into account the shear and slip flow from a tapered needle. Because the fluid flow behavior affects the flow rate, model equations were also developed from regression of experimental data to represent the flow behavior of alginate. The predictions from both the flow behavior equation and flow rate model show close agreement with experimental results. For varying needle diameters and temperatures, the slip effect occurring at the needle wall has a significant effect on the flow rate of alginate during scaffold fabrication.Keywords
Funding Information
- Natural Sciences and Engineering Research Council of Canada (NSERC RGPIN-2014-05)
This publication has 49 references indexed in Scilit:
- Controlled Positioning of Cells in Biomaterials—Approaches Towards 3D Tissue PrintingJournal of Functional Biomaterials, 2011
- Sequential assembly of cell‐laden hydrogel constructs to engineer vascular‐like microchannelsBiotechnology & Bioengineering, 2011
- Characterization of the flow behavior of alginate/hydroxyapatite mixtures for tissue scaffold fabricationBiofabrication, 2009
- Rheological behavior and wall slip of concentrated coal water slurry in pipe flowsChemical Engineering and Processing - Process Intensification, 2009
- Cell Encapsulation in Biodegradable Hydrogels for Tissue Engineering ApplicationsTissue Engineering, Part B: Reviews, 2008
- Porosity of 3D biomaterial scaffolds and osteogenesisBiomaterials, 2005
- Viable Osteogenic Cells Are Obligatory for Tissue-Engineered Ectopic Bone Formation in GoatsTissue Engineering, 2003
- Quantitative analysis of cell proliferation and orientation on substrata with uniform parallel surface micro-groovesBiomaterials, 1996
- Wall slip and the nonlinear dynamics of large amplitude oscillatory shear flowsJournal of Rheology, 1995
- Rheological behavior of a concentrated suspension: A solid rocket fuel simulantJournal of Rheology, 1993