Fragmentation of DNA in P388D1macrophages exposed to oxidised low-density lipoprotein
- 18 October 1993
- journal article
- Published by Wiley in FEBS Letters
- Vol. 332 (3), 218-220
- https://doi.org/10.1016/0014-5793(93)80635-8
Abstract
Exposing a macrophage‐like murine cell line to copper‐oxidised low‐density lipoprotein led to DNA fragmentation which was inhibited by the putative Ca2+/Mg2+ endonuclease inhibitor, zinc sulphate. DNA fragmentation preceded loss of membrane impermeability. These results suggest that apoptosis may be a mechanism of macrophage foam cell death in atherosclerotic lesions in the arterial wall.This publication has 16 references indexed in Scilit:
- Endonuclease-induced DNA damage and cell death in oxidant injury to renal tubular epithelial cells.JCI Insight, 1992
- Oxidized low density lipoproteins elicit DNA fragmentation of cultured lymphoblastoid cellsFEBS Letters, 1992
- Cellular damage in mouse peritoneal macrophages exposed to cholesteryl linoleateAtherosclerosis, 1992
- Dose‐dependent induction of apoptosis in human tumour cell lines by widely diverging stimuliCell Proliferation, 1991
- Apoptosis induced in macrophages and T blasts by the mycotoxin sporidesmin and protection by Zn2+ saltsInternational Journal of Immunopharmacology, 1990
- Apoptosis: Cell death in tissue regulationThe Journal of Pathology, 1987
- Identification of macrophages and smooth muscle cells in human atherosclerosis using monoclonal antibodiesThe Journal of Pathology, 1985
- Endothelial and smooth muscle cells alter low density lipoprotein in vitro by free radical oxidation.Arteriosclerosis: An Official Journal of the American Heart Association, Inc., 1984
- LIPOPROTEIN METABOLISM IN THE MACROPHAGE: Implications for Cholesterol Deposition in AtherosclerosisAnnual Review of Biochemistry, 1983
- Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activationNature, 1980