The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity
Open Access
- 18 September 2017
- journal article
- Published by Elsevier BV in Molecular Metabolism
- Vol. 6 (11), 1468-1479
- https://doi.org/10.1016/j.molmet.2017.09.002
Abstract
No abstract availableKeywords
Funding Information
- NIH (R01 DK104998, R00 AR059190, R01 DK078184)
- Robert A. Welch Foundation (I-1804, F32 DK101183, T32 HL007121, T32 HL007638, T32 HL007344, T32 GM067795, P30CA086862)
This publication has 43 references indexed in Scilit:
- Identification of a Mitochondrial Target of Thiazolidinedione Insulin Sensitizers (mTOT)—Relationship to Newly Identified Mitochondrial Pyruvate Carrier ProteinsPLOS ONE, 2013
- Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrierProceedings of the National Academy of Sciences of the United States of America, 2013
- A Mitochondrial Pyruvate Carrier Required for Pyruvate Uptake in Yeast, Drosophila , and HumansScience, 2012
- Mechanisms for Insulin Resistance: Common Threads and Missing LinksCell, 2012
- Nature of fatty acids in high fat diets differentially delineates obesity-linked metabolic syndrome components in male and female C57BL/6J miceDiabetology & Metabolic Syndrome, 2011
- Excessive Hepatic Mitochondrial TCA Cycle and Gluconeogenesis in Humans with Nonalcoholic Fatty Liver DiseaseCell Metabolism, 2011
- Flux through hepatic pyruvate carboxylase and phosphoenolpyruvate carboxykinase detected by hyperpolarized 13 C magnetic resonanceProceedings of the National Academy of Sciences of the United States of America, 2011
- FGF15/19 Regulates Hepatic Glucose Metabolism by Inhibiting the CREB-PGC-1α PathwayCell Metabolism, 2011
- Cytosolic Phosphoenolpyruvate Carboxykinase Does Not Solely Control the Rate of Hepatic Gluconeogenesis in the Intact Mouse LiverCell Metabolism, 2007
- Design and validation of a histological scoring system for nonalcoholic fatty liver diseaseHepatology, 2005