Complete remission of ALK-negative plasma cell granuloma (inflammatory myofibroblastic tumor) of the lung induced by celecoxib: A case report and review of the literature
Open Access
- 15 March 2013
- journal article
- review article
- Published by Spandidos Publications in Oncology Letters
- Vol. 5 (5), 1672-1676
- https://doi.org/10.3892/ol.2013.1260
Abstract
We report a case in which a 52-year-old female developed a multifocal inflammatory myofibroblastic tumor (IMT) of the lung. The tumor did not overexpress the anaplastic lymphoma kinase (ALK) protein, indicating a lack of ALK rearrangement. The patient required two wedge resections in 15 months due to recurrent disease. Recurrence after the second surgery was treated with corticosteroids, which only led to a transient response (6 months). Introduction of celecoxib, a cyclooxygenase-2 inhibitor, induced a complete remission in the patient. Maintenance on celecoxib further led to a progression-free survival of 34 months. A literature review retrieved a total of eight case reports, comprising ten patients, of IMT of various anatomical sites successfully treated with non-steroidal anti-inflammatory agent (NSAID) therapy. Nine of the ten patients achieved durable complete remission. Remission occurred rapidly and persisted even after termination of NSAID therapy. Although such a successful outcome may only be achieved rarely, a trial of an NSAID should be considered in any patient in whom complete resection is not an option. Our case also demonstrates that NSAID therapy may be successful in a non-ALK rearranged tumor in which ALK inhibition is not an option.Keywords
This publication has 20 references indexed in Scilit:
- Bilateral Multiple Inflammatory Myofibroblastic Tumors of the Lung Successfully Treated with CorticosteroidsLung, 2011
- Rapid regression of duodenal inflammatory myofibroblastic tumor after intravenous ketorolac: case report and review of the literatureJournal of Pediatric Surgery, 2008
- Inflammatory pseudotumor of the liver successfully treated with nonsteroidal anti-inflammatory drugs: A challenge diagnosis for one not so rare entityEuropean Journal of Gastroenterology & Hepatology, 2007
- Inflammatory myofibroblastic tumours: where are we now?Journal of Clinical Pathology, 2007
- Inflammatory Myofibroblastic TumorThe American Journal of Surgical Pathology, 2007
- Cyclo-Oxygenase-2 and its Inhibition in CancerDrugs, 2007
- The rationale for nonsteroidal anti-inflammatory drug therapy for inflammatory myofibroblastic tumors: a Children's Oncology Group studyJournal of Pediatric Surgery, 2005
- Regression of nonresectable inflammatory myofibroblastic tumours after treatment with nonsteroidal anti‐inflammatory drugsEuropean Journal of Clinical Investigation, 2004
- Treatment of pseudotumors with nonsteroidal antiinflammatory drugsJournal of Pediatric Surgery, 2000
- Treatment of plasma cell granuloma of the lung with radiation therapy. A report of two cases and a review of the literatureCancer, 1986