Preferential loss of CXCR-2 receptor expression and function in patients who have undergone trauma.

Abstract

TRAUMA IS recognized as an inflammatory disease.¹ Various mediators and indicators of an inflammatory response are elevated in severely injured patients.^2,3 Many of these factors are significantly higher in patients who eventually died compared with survivors.^1,4-6 Early or prolonged activation of the inflammatory response has been linked to the development of clinical syndromes, such as systemic inflammatory response syndrome, adult respiratory distress syndrome, and multiorgan system failure.