Recombinant GABAA receptor function and ethanol
- 14 June 1993
- journal article
- Published by Wiley in FEBS Letters
- Vol. 324 (2), 140-142
- https://doi.org/10.1016/0014-5793(93)81380-i
Abstract
Different combinations of cloned subunits of the rat brain GABAA receptor were expressed in Xenopus oocytes. Possible effects of ethanol on the expressed GABA-induced chloride current were determined. The consequence of replacing the γ2s subunit by the alternatively spliced variant γ2L was specifically tested on the responsiveness to ethanol. A significant stimulation of the GABA response was only observed at very high concentrations (> 60 mM) of ethanol. No differential response was observed between subunit combinations containing different γ2 subunit splice variants.Keywords
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