Homophilic interaction of the L1 family of cell adhesion molecules
Open Access
- 1 January 2012
- journal article
- review article
- Published by Springer Science and Business Media LLC in Experimental & Molecular Medicine
- Vol. 44 (7), 413-423
- https://doi.org/10.3858/emm.2012.44.7.050
Abstract
Homophilic interaction of the L1 family of cell adhesion molecules plays a pivotal role in regulating neurite outgrowth and neural cell networking in vivo. Functional defects in L1 family members are associated with neurological disorders such as X-linked mental retardation, multiple sclerosis, low-IQ syndrome, developmental delay, and schizophrenia. Various human tumors with poor prognosis also implicate the role of L1, a representative member of the L1 family of cell adhesion molecules, and ectopic expression of L1 in fibroblastic cells induces metastasis-associated gene expression. Previous studies on L1 homologs indicated that four N-terminal immunoglobulin-like domains form a horseshoe-like structure that mediates homophilic interactions. Various models including the zipper, domain-swap, and symmetry-related models are proposed to be involved in structural mechanism of homophilic interaction of the L1 family members. Recently, cryo-electron tomography of L1 and crystal structure studies of neurofascin, an L1 family protein, have been performed. This review focuses on recent discoveries of different models and describes the possible structural mechanisms of homophilic interactions of L1 family members. Understanding structural mechanisms of homophilic interactions in various cell adhesion proteins should aid the development of therapeutic strategies for L1 family cell adhesion molecule-associated diseases.Keywords
This publication has 70 references indexed in Scilit:
- Two Alcohol Binding Residues Interact across a Domain Interface of the L1 Neural Cell Adhesion Molecule and Regulate Cell AdhesionPublished by Elsevier BV ,2011
- Homophilic Adhesion Mechanism of Neurofascin, a Member of the L1 Family of Neural Cell Adhesion MoleculesJournal of Biological Chemistry, 2011
- Cryo-Electron Tomography of Homophilic Adhesion Mediated by the Neural Cell Adhesion Molecule L1Structure, 2009
- The adhesion molecule L1 regulates transendothelial migration and trafficking of dendritic cellsThe Journal of Experimental Medicine, 2009
- Kinetic Analysis of L1 Homophilic InteractionJournal of Biological Chemistry, 2008
- A Double S Shape Provides the Structural Basis for the Extraordinary Binding Specificity of Dscam IsoformsCell, 2008
- L1 and NCAM adhesion molecules as signaling coreceptors in neuronal migration and process outgrowthCurrent Opinion in Neurobiology, 2008
- An alcohol binding site on the neural cell adhesion molecule L1Proceedings of the National Academy of Sciences of the United States of America, 2008
- Neurofascin as a novel target for autoantibody-mediated axonal injuryThe Journal of Experimental Medicine, 2007
- Protein tyrosine phosphatases: from genes, to function, to diseaseNature Reviews Molecular Cell Biology, 2006