Molecular discrimination inside polymer nanotubules
- 3 February 2008
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Nanotechnology
- Vol. 3 (2), 112-117
- https://doi.org/10.1038/nnano.2008.6
Abstract
Recognition of small organic molecules and large biomolecules such as proteins is of great importance in pharmaceutical as well as biological applications. Recognition inside a nanoporous membrane is particularly attractive, because of the advantages associated with ligand–receptor interactions in confined spaces. Classical nanoporous membrane-based separations simply use the difference in size of the analytes relative to pore size in the membrane. In order to bring about selectivity beyond size, it is necessary that methods for functionalizing the membrane pores are readily available. Here, we describe a simple approach to functionalize the nanopores within these membranes using self-assembling and non-self-assembling polymers. We show that these modified membranes separate small molecules based on size, charge and hydrophobicity. We also demonstrate here that proteins can be differentially transported through the nanopores based on their size and/or electrostaticsKeywords
This publication has 30 references indexed in Scilit:
- Facial Control of Nanoparticle Binding to Cytochrome cJournal of the American Chemical Society, 2007
- Supramolecular Assemblies from Amphiphilic Homopolymers: Testing the ScopeJournal of the American Chemical Society, 2006
- Nanoassembly of a Fractal Polymer: A Molecular "Sierpinski Hexagonal Gasket"Science, 2006
- Fabrication of 3D Gold Nanoelectrode Ensembles by Chemical EtchingAnalytical Chemistry, 2005
- Electrochemical and Transport Properties of Templated Gold/Polypyrrole-Composite Microtube MembranesJournal of the Electrochemical Society, 2004
- Nano Wheat Fields Prepared by Plasma-Etching Gold Nanowire-Containing MembranesNano Letters, 2003
- Convergent Solutions to Binding at a Protein-Protein InterfaceScience, 2000
- Effect of Thiol Chemisorption on the Transport Properties of Gold Nanotubule MembranesAnalytical Chemistry, 1999
- Catalysis of Nucleobase via Multiple Hydrogen-Bonding Interactions: Acceleration of Aminolysis of 6-Chloropurine Derivatives by UracilsJournal of the American Chemical Society, 1999
- Introducing Chemical Transport Selectivity into Gold Nanotubule MembranesJournal of the American Chemical Society, 1998