Impact of Local versus Global Ligand Density on Cellular Adhesion
- 22 March 2011
- journal article
- research article
- Published by American Chemical Society (ACS) in Nano Letters
- Vol. 11 (4), 1469-1476
- https://doi.org/10.1021/nl104079r
Abstract
αvβ3 integrin-mediated cell adhesion is crucially influenced by how far ligands are spaced apart. To evaluate the impact of local ligand density versus global ligand density of a given surface, we used synthetic micronanostructured cell environments with user-defined ligand spacing and patterns to investigate cellular adhesion. The development of stable focal adhesions, their number, and size as well as the cellular adhesion strength proved to be influenced by local more than global ligand density.Keywords
This publication has 40 references indexed in Scilit:
- Cell Adhesion Strength Is Controlled by Intermolecular Spacing of Adhesion ReceptorsBiophysical Journal, 2010
- Impact of Order and Disorder in RGD Nanopatterns on Cell AdhesionNano Letters, 2009
- Cell interactions with hierarchically structured nano-patterned adhesive surfacesSoft Matter, 2008
- Cell adhesion and response to synthetic nanopatterned environments by steering receptor clustering and spatial locationHFSP Journal, 2008
- Physical Interpretation of the Maximum Receptor−Ligand Bond Spacing to Ensure Cell Adhesion in Ligand-Coated SubstratesLangmuir, 2008
- Functional atlas of the integrin adhesomeNature, 2007
- Cell Spreading and Focal Adhesion Dynamics Are Regulated by Spacing of Integrin LigandsBiophysical Journal, 2007
- Local force and geometry sensing regulate cell functionsNature Reviews Molecular Cell Biology, 2006
- Noble metal loaded block lonomers: micelle organization, adsorption of free chains and formation of thin films**Advanced Materials, 1995
- Integrins: Versatility, modulation, and signaling in cell adhesionCell, 1992