Kinetic constraints on possible reaction pathways for osmium-catalysed asymmetric dihydroxylation

Abstract
Proposed mechanisms for the osmium-catalysed dihydroxylation are examined and kinetic rate laws derived in terms of various mechanistic rate constants. In light of the reported kinetic behaviour of these systems, particularly with asymmetric nitrogen base ligands, several constraints can be placed on the two major competing hypotheses. The chemical consequences of these constraints make stepwise formation of the two C–O bonds via an osmaoxetane the more plausible mechanistic model.