Determination of organochlorine pesticides and metabolites in drinking water, human blood serum, and adipose tissue

Abstract

Previously published analytical procedures by which drinking water, human blood serum and adipose tissue may be analyzed for trace amounts of organochlorine pesticides were modified to permit use of smaller samples. Data on percent recovery, detector sensitivity and limit of detectability were collected for each of the 3 reported procedures. The methodology was applied to 59 blood samples, 20 drinking water samples and 10 necropsy adipose tissue samples. Only hexachlorobenzene and dieldrin were detected in water. Hexachlorobenzene, .beta.-HBC, dieldrin, p,p''-DDE and p,p''-DDT were present in blood. No heptachlor, heptachlor epoxide, oxychlordane, trans-nonachlor or o,p''-DDT was found. In fat, the compounds present in blood plus oxychlordane, heptachlor epoxide and trans-nonachlor were detected. No heptachlor, aldrin, o,p''-DDT or .alpha.- or .gamma.-chlordane was present. Reported values were representative of the levels of persistent organochlorine pesticides and pesticide metabolites found in 1978 in white female residents of Dade County, Florida [USA].