Monoamine oxidase inhibitors and histamine metabolism
- 1 July 1980
- journal article
- Published by Springer Science and Business Media LLC in Cellular and Molecular Life Sciences
- Vol. 36 (7), 818-820
- https://doi.org/10.1007/bf01978589
Abstract
In the rat, histamine metabolism is altered by some nonspecific inhibitors of monoamine oxidase (MAO) such as iproniazid, and, to a lesser extent, tranylcypromine. Type A MAO inhibitors, such as clorgyline and MD780515, do not seem to interfere with the metabolism of histamine. Deprenyl, a type B MAO inhibitor, shows some inhibition which is, however, much lower than that observed with iproniazid. The strong effect of iproniazid is probably due to its DAO inhibiting properties.Keywords
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