Bidirectional contact tracing could dramatically improve COVID-19 control
Open Access
- 11 January 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Communications
- Vol. 12 (1), 1-9
- https://doi.org/10.1038/s41467-020-20325-7
Abstract
Contact tracing is critical to controlling COVID-19, but most protocols only “forward-trace” to notify people who were recently exposed. Using a stochastic branching-process model, we find that “bidirectional” tracing to identify infector individuals and their other infectees robustly improves outbreak control. In our model, bidirectional tracing more than doubles the reduction in effective reproduction number (Reff) achieved by forward-tracing alone, while dramatically increasing resilience to low case ascertainment and test sensitivity. The greatest gains are realised by expanding the manual tracing window from 2 to 6 days pre-symptom-onset or, alternatively, by implementing high-uptake smartphone-based exposure notification; however, to achieve the performance of the former approach, the latter requires nearly all smartphones to detect exposure events. With or without exposure notification, our results suggest that implementing bidirectional tracing could dramatically improve COVID-19 control.Keywords
Funding Information
- Fellowship from the Open Philanthropy Project https://www.openphilanthropy.org/
- The Drexel Endowment at North Carolina State University supports the work of Professor Lloyd.
- The Reid Hoffman Foundation and Open Philanthropy Project contributed gifts to the Esvelt laboratory. https://www.openphilanthropy.org/
This publication has 44 references indexed in Scilit:
- Indirect Virus Transmission in Cluster of COVID-19 Cases, Wenzhou, China, 2020Emerging Infectious Diseases, 2020
- The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and ApplicationAnnals of Internal Medicine, 2020
- Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected PneumoniaThe New England Journal of Medicine, 2020
- SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected PatientsThe New England Journal of Medicine, 2020
- Estimating the asymptomatic proportion of coronavirus disease 2019 (COVID-19) cases on board the Diamond Princess cruise ship, Yokohama, Japan, 2020Eurosurveillance, 2020
- Comparative Impact of Individual Quarantine vs. Active Monitoring of Contacts for the Mitigation of COVID-19: a modelling studyPublished by Cold Spring Harbor Laboratory ,2020
- Clinical characteristics of 24 asymptomatic infections with COVID-19 screened among close contacts in Nanjing, ChinaScience China Life Sciences, 2020
- Feasibility of controlling COVID-19 outbreaks by isolation of cases and contactsThe Lancet. Global Health, 2020
- The effect of delay on contact tracingMathematical Biosciences, 2016
- Contact tracing using provider referral: how difficult is it?Sexual Health, 2013