Pregnancy rates and predictors of conception, miscarriage and abortion in US women with HIV

Abstract

To determine frequency and outcomes of pregnancy in US women with HIV before and after introduction of highly active antiretroviral therapy (HAART). Prospective cohort study at six US centers. HIV seropositive and at-risk seronegative women reported pregnancy outcomes at 6-month intervals during the period 1 October 1994 to 31 March 2002. Outcomes were tabulated and pregnancy rates calculated. Logistic regression defined outcome correlates. Pregnancy rates were 7.4 and 15.2 per 100 person-years in seropositive and seronegative women, respectively (P P Women with HIV were less likely to conceive than at-risk uninfected women, but pregnancy outcomes were similar. Abortion became less common after the introduction of HAART.