Zinc is required in pyrrolidine dithiocarbamate inhibition of NF‐κB activation
Open Access
- 16 April 1999
- journal article
- Published by Wiley in FEBS Letters
- Vol. 449 (1), 28-32
- https://doi.org/10.1016/s0014-5793(99)00390-7
Abstract
Pyrrolidine dithiocarbamate (PDTC) is a potent inhibitor of nuclear factor kappa B (NF-κB) activation. PDTC inhibited basal NF-κB activity of endothelial cells. PDTC, however, failed to inhibit basal NF-κB activity after withdrawal of serum in the media, and the inhibitory effect of PDTC could be restored by addition of zinc. When various preparations of metal ion-EDTA were tested with PDTC in serum-containing media, only Zn-EDTA failed to block the inhibitory effect of PDTC. The dependence on zinc was also noted in PDTC inhibition of NF-κB stimulated by TNFα. These facts suggest that zinc is required for PDTC inhibition of NF-κB activation.Keywords
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