Determinants of protein function revealed by combinatorial entropy optimization
Open Access
- 31 December 2006
- journal article
- research article
- Published by Springer Science and Business Media LLC in Genome Biology
- Vol. 8 (11), R232-15
- https://doi.org/10.1186/gb-2007-8-11-r232
Abstract
We use a new algorithm (combinatorial entropy optimization [CEO]) to identify specificity residues and functional subfamilies in sets of proteins related by evolution. Specificity residues are conserved within a subfamily but differ between subfamilies, and they typically encode functional diversity. We obtain good agreement between predicted specificity residues and experimentally known functional residues in protein interfaces. Such predicted functional determinants are useful for interpreting the functional consequences of mutations in natural evolution and disease.Keywords
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