Differential Renal Function Estimation Using Computerized Tomography Based Renal Parenchymal Volume Measurement
- 30 June 2010
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of Urology
- Vol. 183 (6), 2289-2293
- https://doi.org/10.1016/j.juro.2010.02.024
Abstract
Purpose: Nuclear renal scan is currently the gold standard imaging study to determine differential renal function. We propose helical computerized tomography as a more efficient way to gain renal function information. Renal parenchymal volume is measured and percent total renal volume is used as a surrogate marker for differential renal function. Materials and Methods: Computerized tomography and diuretic enhanced nuclear renal scan were performed in 33 patients with chronic obstruction. Computerized tomography was contrast enhanced in 23 cases and nonenhanced in 10. Diagnoses included ureteropelvic junction obstruction, ureteral stricture and extrinsic compression. Using semiautomated boundary delineation with manual editing method the parenchymal volume of each kidney was measured and percent renal volume was calculated. Percent renal volume was compared with percent renal function, as determined by nuclear renal scan. Correlations between the 2 measures were evaluated using the Spearman or Pearson coefficient. Results: Strong correlations were observed between percent renal function and percent renal volume in all cases (r = 0.90, p <0.001), including the enhanced (r = 0.87, p <0.001) and nonenhanced (r = 0.95, p <0.001) groups. Moderately strong correlations were noted in the less than 40% (r = 0.76, p <0.001) and less than 30% (r = 0.64, p = 0.015) renal function subgroups. Conclusions: Differential renal volume measured from computerized tomography strongly correlates with differential renal function on nuclear renal scan for normal and chronically obstructed kidneys. Computerized tomography may serve as a single radiological diagnostic study for anatomical and functional assessment in patients in whom a poorly functioning kidney is suspected.Keywords
This publication has 10 references indexed in Scilit:
- ACR Colon Cancer Committee White Paper: Status of CT Colonography 2009Journal of the American College of Radiology, 2009
- Renal Function Assessment in the Era of Chronic Kidney Disease: Renewed Emphasis on Renal Function Centered Patient CareJournal of Urology, 2009
- Estimating Glomerular Filtration Rate in Kidney Donors: A Model Constructed with Renal Volume Measurements from Donor CT ScansRadiology, 2009
- CONTRAST ENHANCED SPIRAL COMPUTERIZED TOMOGRAPHY IN PATIENTS WITH CHRONIC OBSTRUCTIVE UROPATHY AND NORMAL SERUM CREATININE: A SINGLE SESSION FOR ANATOMICAL AND FUNCTIONAL ASSESSMENTJournal of Urology, 2004
- Prediction of differential creatinine clearance in chronically obstructed kidneys by non-contrast helical computerized tomographyInternational braz j urol, 2004
- Glomerular Filtration Rate Measured by Using Triphasic Helical CT with a Two-Point Patlak Plot TechniqueRadiology, 2004
- Use of spiral CT and the contrast medium iohexol to determine in one session aortorenal morphology and the relative glomerular filtration rate of each kidneyEuropean Radiology, 2001
- Functional CT of the kidneyEuropean Journal of Radiology, 1999
- Utility of CT angiography for evaluation of living kidney donorsClinical Transplantation, 1999
- INTERACTIVE 3-DIMENSIONAL COMPUTERIZED TOMOGRAPHY RECONSTRUCTION IN EVALUATION OF THE LIVING RENAL DONORJournal of Urology, 1999