Chronic Kidney Disease and Health Status Outcomes Following Acute Myocardial Infarction
Open Access
- 6 May 2016
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of the American Heart Association
- Vol. 5 (5)
- https://doi.org/10.1161/jaha.115.002772
Abstract
Background The association between chronic kidney disease ( CKD ) and health status outcomes after acute myocardial infarction ( AMI ) is unknown. Methods and Results Patients were enrolled between 2005 and 2008 in the Translational Research Investigating Underlying Disparities in Acute Myocardial Infarction Patients' Health Status (TRIUMPH) registry, a prospective multicenter observational study of AMI outcomes. The Seattle Angina Questionnaire and Short Form‐12 were collected at baseline and at 1, 6, and 12 months following AMI . CKD was defined by an estimated glomerular filtration rate <60 mL/min, calculated during the AMI hospitalization. Linear repeated‐measures models assessed the association between CKD and health status after AMI , accounting for the propensity to have follow‐up heath status measures. Of 3617 patients, 576 (16%) had CKD and 3041 (84%) did not have CKD . Patients with CKD were older and had more comorbidity. Patients with CKD were more likely to have multivessel coronary disease and less likely to undergo revascularization. Among AMI survivors, patients with and without CKD had similar health‐related quality of life (adjusted difference of 0.24, 95% CI −1.46 to 1.95), angina frequency (adjusted difference of 1.27, 95% CI −0.05 to 2.58), and mental health (adjusted difference of −0.07, 95% CI −0.90 to 0.75). In contrast, patients with CKD had lower physical health (adjusted difference −1.61, 95% CI −2.49 to −0.74), which was not clinically significant, compared with patients without CKD . Conclusions Among AMI survivors, patients with CKD not only had more comorbidities but also, after adjusting for these patient differences, had similar health status compared with patients without CKD . Interventions aimed at improving health status after AMI should not focus on CKD status.Keywords
This publication has 19 references indexed in Scilit:
- Quality of Care and Outcomes Among Patients With Acute Myocardial Infarction by Level of Kidney Function at Admission: Report From the Get With The Guidelines Coronary Artery Disease ProgramClinical Cardiology, 2012
- Physical function and independence 1 year after myocardial infarction: Observations from the Translational Research Investigating Underlying disparities in recovery from acute Myocardial infarction: Patients' Health status registryAmerican Heart Journal, 2012
- Health-related quality of life in different stages of chronic kidney disease and at initiation of dialysis treatmentHealth and Quality of Life Outcomes, 2012
- Translational Research Investigating Underlying Disparities in Acute Myocardial Infarction Patients' Health Status (TRIUMPH)Circulation: Cardiovascular Quality and Outcomes, 2011
- Review of inverse probability weighting for dealing with missing dataStatistical Methods in Medical Research, 2011
- Chronic Kidney Disease and the Risks of Death, Cardiovascular Events, and HospitalizationThe New England Journal of Medicine, 2004
- Comparison of 50-mg and 100-mg Sustained-Release Isosorbide Mononitrate in the Treatment of Stable Angina Pectoris: Effects on Quality-of-Life IndicesAngiology, 1999
- A 12-Item Short-Form Health SurveyMedical Care, 1996
- Development and evaluation of the Seattle Angina questionnaire: A new functional status measure for coronary artery diseaseJournal of the American College of Cardiology, 1995
- Monitoring the quality of life in patients with coronary artery diseaseThe American Journal of Cardiology, 1994