Efficacy of endoscopic ultrasound-guided fine-needle aspiration for schwannoma: six cases of a retrospective study
Open Access
- 1 January 2017
- journal article
- Published by The Fukushima Society of Medical Science in FUKUSHIMA JOURNAL OF MEDICAL SCIENCE
- Vol. 63 (2), 75-80
- https://doi.org/10.5387/fms.2015-21
Abstract
Schwannomas are difficult to diagnose using imaging alone. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is an effective and safe tissue sampling technique. Nevertheless, few reports have described EUS-FNA for schwannoma. This study evaluates the efficacy of EUS-FNA for diagnosing schwannoma. This retrospective study examined six consecutive schwannoma patients who were diagnosed as having schwannoma either from EUS-FNA results or from surgically resected specimens. The primary endpoint was diagnostic accuracy of EUS-FNA for schwannoma. The secondary endpoint was EUS-FNA safety. Based on cytomorphologic features and immunocytochemistry results after EUS-FNA, 4 out of 6 patients (66.7%) were diagnosed with schwannoma. The diagnoses before EUS-FNA were the following: 3 cases of gastric subepithelial lesion (SEL, suspicious for gastrointestinal stromal tumor), 1 case of intraperitoneal tumor, 1 case of retroperitoneal tumor, and 1 case of pancreatic tumor, with sizes of 15-44 mm (median 36 mm). No case was diagnosed as schwannoma solely based on image findings. Two cases of gastric SELs could not be diagnosed as schwannoma by EUS-FNA before surgery. Inadequate sampling and a lack of additional material for immunohistochemical studies could have engendered less-definite diagnoses in those cases. No procedural adverse events occurred. The diagnostic accuracy rate of EUS-FNA for schwannoma is somewhat low. However, tissue samples were obtained safely using this method. Moreover, it is an important procedure for diagnosing schwannoma, which cannot be diagnosed solely from image findings.Keywords
This publication has 13 references indexed in Scilit:
- Management and prognosis of malignant peripheral nerve sheath tumors: The experience of the French Sarcoma Group (GSF-GETO)European Journal of Cancer, 2016
- Gastric schwannoma: a case report and literature review.2012
- Three cases of retroperitoneal schwannoma diagnosed by EUS-FNAWorld Journal of Gastroenterology, 2011
- Mediastinal Schwannoma Diagnosed by Endoscopic Ultrasonography-Guided Fine Needle Aspiration CytologyCase Reports in Gastroenterology, 2011
- Endoscopic ultrasound-guided fine-needle aspiration of solid pancreatic masses with rapid on-site cytological evaluation by endosonographers without attendance of cytopathologistsThe Esophagus, 2009
- Presacral schwannoma diagnosed by EUS-guided FNAGastrointestinal Endoscopy, 2008
- Schwannoma of the mediastinum diagnosed by EUS-guided fine needle aspirationGastrointestinal Endoscopy, 2001
- Upper gastrointestinal bleeding due to a malignant Schwannoma of the stomachEuropean Journal of Gastroenterology & Hepatology, 1998
- Cellular schwannoma. A clinicopathologic study of 57 patients and 58 tumorsCancer, 1990
- Cellular schwannoma: a distinct pseudosarcomatous entityHistopathology, 1987