The relevance of murine animal models to study the development of allergic bronchial asthma
- 1 April 1996
- journal article
- review article
- Published by Wiley in Immunology & Cell Biology
- Vol. 74 (2), 209-217
- https://doi.org/10.1038/icb.1996.30
Abstract
Bronchial asthma (BA) develops on the basis of a genetic predisposition and involves a characteristic sequence of changes in immune functions. In the immunopathogenesis, several phases can be distinguished: the initial stage is defined as the development of allergic sensitization. This step is dependent on: (i) T cell activation; (ii) IL-4 production; (iii) IgE synthesis; and (iv) mediator release by effector cells. The second phase of allergic inflammation as a consequence of the T cell dependent sensitization is characterized by IL-5 production and eosinophil activation and recruitment. Airway mucosa remodelling is the consequence of chronic inflammatory processes and represents the final stage of BA. In this article animal models will be discussed with regard to their relevance for these different phases in development of chronic allergic BA.Keywords
This publication has 59 references indexed in Scilit:
- Genetic Susceptibility to Asthma — Bronchial Hyperresponsiveness Coinherited with a Major Gene for AtopyNew England Journal of Medicine, 1995
- Time course study for antigen-induced airway hyperreactivity and the effect of soluble IL-5 receptorLife Sciences, 1994
- Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cellsImmunology Today, 1994
- Effect of anti-IL-5 monoclonal antibody on allergic bronchial eosinophilia and airway hyperresponsiveness in miceLife Sciences, 1993
- Predominant TH2-like Bronchoalveolar T-Lymphocyte Population in Atopic AsthmaNew England Journal of Medicine, 1992
- Generation and Analysis of Interleukin-4 Deficient MiceScience, 1991
- A recombinant extracellular domain of the human interleukin 4 receptor inhibits the biological effects of interleukin 4 on T and B lymphocytesEuropean Journal of Immunology, 1991
- Human immune responsiveness to Lolium Perenne pollen allergen Lol p III (Rye III) is associated with HLA-DR3 and DR5Human Immunology, 1989
- Association of Asthma with Serum IgE Levels and Skin-Test Reactivity to AllergensNew England Journal of Medicine, 1989
- Release of Prostaglandin D2into Human Airways during Acute Antigen ChallengeNew England Journal of Medicine, 1986