Identification and Clinical Impact of Multiple Sclerosis Cortical Lesions as Assessed by Routine 3T MR Imaging
Open Access
- 10 February 2011
- journal article
- Published by American Society of Neuroradiology (ASNR) in American Journal Of Neuroradiology
- Vol. 32 (3), 515-521
- https://doi.org/10.3174/ajnr.a2340
Abstract
BACKGROUND AND PURPOSE: Histopathologic studies have reported widespread cortical lesions in MS; however, in vivo detection by using routinely available pulse sequences is challenging. We investigated the relative frequency and subtypes of cortical lesions and their relationships to white matter lesions and cognitive and physical disability. MATERIALS AND METHODS: Cortical lesions were identified and classified on the basis of concurrent review of 3D FLAIR and 3D T1-weighted IR-SPGR 3T MR images in 26 patients with MS. Twenty-five patients completed the MACFIMS battery. White matter lesion volume, cortical lesion number, and cortical lesion volume were assessed. RESULTS: Overall, 249 cortical lesions were detected. Cortical lesions were present in 24/26 patients (92.3%) (range per patient, 0–30; mean, 9.6 ± 8.8). Most (94.4%, n = 235) cortical lesions were classified as mixed cortical-subcortical (type I); the remaining 5.6% (n = 14) were classified as purely intracortical (type II). Subpial cortical lesions (type III) were not detected. White matter lesion volume correlated with cortical lesion number and cortical lesion volume (rS = 0.652, rS = 0.705, respectively; both P < .001). After controlling for age, depression, and premorbid intelligence, we found that all MR imaging variables (cortical lesion number, cortical lesion volume, white matter lesion volume) correlated with the SDMT score (R2 = 0.513, R2 = 0.449, R2 = 0.418, respectively; P < .014); cortical lesion number also correlated with the CVLT-II scores (R2 = 0.542–0.461, P < .043). The EDSS scores correlated with cortical lesion number and cortical lesion volume (rS = 0.472, rS = 0.404, respectively; P < .05), but not with white matter lesion volume. CONCLUSIONS: Our routinely available imaging method detected many cortical lesions in patients with MS and was useful in their precise topographic characterization in the context of the gray matter−white matter junction. Routinely detectable cortical lesions were related to physical disability and cognitive impairment.Keywords
This publication has 43 references indexed in Scilit:
- Gray matter involvement in multiple sclerosisNeurology, 2007
- Extensive Cortical Remyelination in Patients with Chronic Multiple SclerosisBrain Pathology, 2007
- Neocortical neuronal, synaptic, and glial loss in multiple sclerosisNeurology, 2006
- Cortical demyelination and diffuse white matter injury in multiple sclerosisBrain, 2005
- Subpial Demyelination in the Cerebral Cortex of Multiple Sclerosis PatientsJournal of Neuropathology and Experimental Neurology, 2003
- Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesionsAnnals of Neurology, 2001
- Fluid-Attenuated Inversion Recovery Magnetic Resonance Imaging Detects Cortical and Juxtacortical Multiple Sclerosis LesionsArchives of Neurology, 2001
- Cortical lesions in multiple sclerosisBrain, 1999
- Axonal Transection in the Lesions of Multiple SclerosisThe New England Journal of Medicine, 1998
- The distribution of plaques in the cerebrum in multiple sclerosisJournal of Neurology, Neurosurgery & Psychiatry, 1962