Expanding the Nucleotide Repertoire of the Ribosome with Post-Transcriptional Modifications

Publisher Website

1 September 2007

journal article
review article
Published by American Chemical Society (ACS) in ACS Chemical Biology

Vol. 2 (9), 610-619
https://doi.org/10.1021/cb7001494

Abstract

No abstract available

Keywords

RIBOSOME: RIBONUCLEOPROTEIN COMPLEXES (RRNA AND PROTEINS) THAT MANUFACTURE PROTEINS; THEY CONTAIN A SMALL SUBUNIT (SSU) AND A LARGE SUBUNIT (LSU).
PEPTIDYL-TRANSFERASE CENTER: THE CATALYTIC CENTER OF THE RIBOSOME; IT IS LOCATED ON THE LARGE RIBOSOMAL SUBUNIT AND CATALYZES PEPTIDE-BOND FORMATION AND PEPTIDE RELEASE.
DECODING REGION: LOCATED ON THE SSU RRNA AND CONTAINS HIGHLY CONSERVED NUCLEOTIDES THAT ARE INVOLVED IN INTERACTIONS WITH TRANSFER RNAS (TRNAS) AND MESSENGER RNA. THE A SITE BINDS TO AMINOACYL-TRNA. THE P SITE BINDS TO PEPTIDYL-TRNA.
INTERSUBUNIT BRIDGES: RNA–RNA AND RNA–PROTEIN INTERACTIONS AT THE INTERFACE FORMED UPON ASSOCIATION OF THE LSU AND SSU DURING TRANSLATION.
PSEUDOURIDYLATION: THE ISOMERIZATION OF URIDINES WITHIN RNA TO PSEUDOURIDINE (Ψ) BY RNA ENZYMES KNOWN AS Ψ SYNTHASES.
METHYLTRANSFERASES: MTASES CATALYZE HIGHLY SPECIFIC TRANSFER OF A METHYL GROUP FROM THE COFACTOR S-ADENOSYL-L-METHIONINE TO THE -O, -C, OR -N POSITION OF A TARGET NUCLEOTIDE.
SMALL NUCLEOLAR RNAS: SNORNAS ARE A CLASS OF SMALL NONCODING RNA MOLECULES THAT GUIDE CHEMICAL MODIFICATION (E.G., METHYLATION OR PSEUDOURIDYLATION) OF EUKARYOTIC RRNAS.

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