Non-motor Parkinson's: integral to motor Parkinson's, yet often neglected
Open Access
- 3 April 2014
- journal article
- review article
- Published by BMJ in Practical Neurology
- Vol. 14 (5), 310-322
- https://doi.org/10.1136/practneurol-2013-000741
Abstract
Non-motor symptoms are a key component of Parkinson's disease, possibly representing a clinical biomarker of its premotor phase. The burden of non-motor symptoms can define a patient's health-related quality of life. Non-motor symptoms substantially increase the cost of care—requiring increased hospitalisation and treatment—and pose a major challenge to healthcare professionals. However, clinicians often regard non-motor symptoms and their management as peripheral to that of the motor symptoms. Here, we address the clinical issues and unmet needs of non-motor symptoms in Parkinson's disease.Keywords
This publication has 56 references indexed in Scilit:
- The Heterogeneity of Early Parkinson’s Disease: A Cluster Analysis on Newly Diagnosed Untreated PatientsPLOS ONE, 2013
- A Proposal for a Comprehensive Grading of Parkinson's Disease Severity Combining Motor and Non-Motor Assessments: Meeting an Unmet NeedPLOS ONE, 2013
- Premotor Parkinson's disease: Concepts and definitionsMovement Disorders, 2012
- A Progressive Mouse Model of Parkinson's Disease: The Thy1-aSyn (“Line 61”) MiceNeurotherapeutics, 2012
- A randomized, double-blind, placebo-controlled trial of antidepressants in Parkinson diseaseNeurology, 2012
- Parkinson’s disease: The non-motor issuesParkinsonism & Related Disorders, 2011
- Animal models of Parkinson's disease: a source of novel treatments and clues to the cause of the diseaseBritish Journal of Pharmacology, 2011
- Rotigotine effects on early morning motor function and sleep in Parkinson's disease: A double‐blind, randomized, placebo‐controlled study (RECOVER)Movement Disorders, 2010
- Progression of Parkinson's Disease Pathology Is Reproduced by Intragastric Administration of Rotenone in MicePLOS ONE, 2010
- Erectile Function and Risk of Parkinson's DiseaseAmerican Journal of Epidemiology, 2007