The Obesity and Fatty Liver Are Reduced by Plant-Derived Pediococcus pentosaceus LP28 in High Fat Diet-Induced Obese Mice
Open Access
- 17 February 2012
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 7 (2), e30696
- https://doi.org/10.1371/journal.pone.0030696
Abstract
We evaluated the effect of an oral administration of a plant-derived lactic acid bacterium, Pediococcus pentosaceus LP28 (LP28), on metabolic syndrome by using high fat diet-induced obese mice. The obese mice were divided into 2 groups and fed either a high fat or regular diet for 8 weeks. Each group was further divided into 3 groups, which took LP28, another plant-derived Lactobacillus plantarum SN13T (SN13T) or no lactic acid bacteria (LAB). The lean control mice were fed a regular diet without inducing obesity prior to the experiment. LP28 reduced body weight gain and liver lipid contents (triglyceride and cholesterol), in mice fed a high fat diet for 8 weeks (40%, 54%, and 70% less than those of the control group without LAB, and P = 0.018, PP = 0.021, respectively), whereas SN13T and the heat treated LP28 at 121°C for 15 min were ineffective. Abdominal visceral fat in the high fat diet mice fed with LP28 was also lower than that without LAB by 44%, although it was not significant but borderline (P = 0.076). The sizes of the adipocytes and the lipid droplets in the livers were obviously decreased. A real-time PCR analyses showed that lipid metabolism-related genes, such as CD36 (P = 0.013), SCD1 encoding stearoyl-CoA desaturase 1 (not significant but borderline, P = 0.066), and PPARγ encoding peroxisome proliferator-activated receptor gamma (P = 0.039), were down-regulated by taking LP28 continuously, when compared with those of the control group. In conclusion, LP28 may be a useful LAB strain for the prevention and reduction of the metabolic syndrome.This publication has 33 references indexed in Scilit:
- Improvement of constipation and liver function by plant-derived lactic acid bacteria: A double-blind, randomized trialNutrition, 2010
- Characterization of four plasmids harboured in a Lactobacillus brevis strain encoding a novel bacteriocin, brevicin 925A, and construction of a shuttle vector for lactic acid bacteria and Escherichia coliMicrobiology, 2009
- Absence of stearoyl-CoA desaturase-1 ameliorates features of the metabolic syndrome in LDLR-deficient miceJournal of Lipid Research, 2008
- Dose translation from animal to human studies revisitedThe FASEB Journal, 2007
- The application of probiotics in cancerBritish Journal of Nutrition, 2007
- Synopsis of the 2006 Canadian clinical practice guidelines on the management and prevention of obesity in adults and childrenCMAJ : Canadian Medical Association Journal, 2007
- Characterization of Lactobacillus plantarum PH04, a potential probiotic bacterium with cholesterol-lowering effectsInternational Journal of Food Microbiology, 2007
- Phenotypic and molecular characterization of Lactococcus lactis from milk and plantsJournal of Applied Microbiology, 2006
- Liver Peroxisome Proliferator-activated Receptor γ Contributes to Hepatic Steatosis, Triglyceride Clearance, and Regulation of Body Fat MassJournal of Biological Chemistry, 2003
- Role for Stearoyl-CoA Desaturase-1 in Leptin-Mediated Weight LossScience, 2002